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NFL ODDS WEEK 1

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Game Lines
FRI SEP 5TH
Spread
Total
Moneyline
12:20AM
DAL Cowboys
+7
−110
O 46.5
−110
+270
12:20AM
PHI Eagles
-7
−110
U 46.5
−110
−340
SAT SEP 6TH
Spread
Total
Moneyline
12:00AM
KC Chiefs
-2.5
−110
O 45.5
−110
−142
12:00AM
LA Chargers
+2.5
−110
U 45.5
−110
+120
SUN SEP 7TH
Spread
Total
Moneyline
5:00PM
CIN Bengals
-5.5
−110
O 44.5
−115
−230
5:00PM
CLE Browns
+5.5
−110
U 44.5
−105
+190
5:00PM
NY Giants
+6.5
−105
O 45.5
−110
+240
5:00PM
WAS Commanders
-6.5
−115
U 45.5
−110
−298
5:00PM
PIT Steelers
-3
−102
O 39.5
−110
−162
5:00PM
NY Jets
+3
−118
U 39.5
−110
+136
5:00PM
ARI Cardinals
-5.5
−110
O 42.5
−110
−238
5:00PM
NO Saints
+5.5
−110
U 42.5
−110
+195
5:00PM
TB Buccaneers
-2.5
−110
O 48.5
−110
−130
5:00PM
ATL Falcons
+2.5
−110
U 48.5
−110
+110
5:00PM
LV Raiders
+3
−105
O 42.5
−110
+140
5:00PM
NE Patriots
-3
−115
U 42.5
−110
−166
5:00PM
CAR Panthers
+3
−112
O 45.5
−115
+136
5:00PM
JAX Jaguars
-3
−108
U 45.5
−105
−162
5:00PM
MIA Dolphins
+1.5
−120
O 45.5
−110
−108
5:00PM
IND Colts
-1.5
+100
U 45.5
−110
−112
8:05PM
TEN Titans
+7.5
−105
O 41.5
−110
+300
8:05PM
DEN Broncos
-7.5
−115
U 41.5
−110
−380
8:05PM
SF 49ers
-1.5
−110
O 45.5
−110
−122
8:05PM
SEA Seahawks
+1.5
−110
U 45.5
−110
+102
8:25PM
DET Lions
+1.5
−110
O 48.5
−110
+102
8:25PM
GB Packers
-1.5
−110
U 48.5
−110
−122
8:25PM
HOU Texans
+3
−110
O 45.5
−110
+136
8:25PM
LA Rams
-3
−110
U 45.5
−110
−162
MON SEP 8TH
Spread
Total
Moneyline
12:20AM
BAL Ravens
+1.5
−110
O 51.5
−110
+102
12:20AM
BUF Bills
-1.5
−110
U 51.5
−110
−122
TUE SEP 9TH
Spread
Total
Moneyline
12:15AM
MIN Vikings
+1.5
−115
O 44.5
−110
+100
12:15AM
CHI Bears
-1.5
−105
U 44.5
−110
−120
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NFL Week 1 Odds & Betting

Find your NFL odds for Week 1 on DraftKings Sportsbook!

The 2025 season kicks off with a Thursday Night Football matchup in Philadelphia as the defending champion Eagles , led by their electric backfield duo of Jalen Hurts and Saquon Barkley, face off against Dak Prescott and the Dallas Cowboys in a heated NFC East rivalry. The Eagles enter this game as heavy favorites according to the NFL Week 1 odds

For the second year in a row, the NFL returns to Brazil with an AFC West matchup featuring  Patrick Mahomes and the Kansas City Chiefs against Justin Herbert and the Los Angeles Chargers in what odds are saying should be a very close game.

Highlighting the rest of the slate, Aaron Rodgers makes his return to MetLife Stadium - this time leading his new team, the Pittsburgh Steelers, against his former team, the New York Jets, now led by  new signal-caller Justin Fields. This game marks the first time in NFL history that two starting quarterbacks who switched teams from the previous year will face off in the following year’s opener.

Sunday Night Football features two of the top AFC contenders  as Lamar Jackson and the Baltimore Ravens head to Buffalo to take on Josh Allen and the Buffalo Bills in a rematch of last year’s Divisional Round.

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