Find NFL odds for Week 2 on DraftKings Sportsbook!

Week 2 of the NFL season kicks off with a Thursday Night Football showdown as Jared Goff and the Detroit Lions travel to Buffalo to take on Josh Allen’s Bills. Two of the league's top contenders square off in the first regular-season game at the Bills' new Highmark Stadium, with the latest NFL Week 2 odds projecting a slight edge for the Bills. 

One of Sunday's top matchups features an NFC West divisional battle as the defending Super Bowl champion Seattle Seahawks travel to Arizona to face the Cardinals. Cardinals rookie Jeremiyah Love made history before taking an NFL snap by signing the largest guaranteed contract ever for a running back, adding even more intrigue to this divisional showdown. 

Sunday Night Football features Daniel Jones and the Indianapolis Colts taking on Patrick Mahomes and the Kansas City Chiefs in a matchup between two AFC playoff hopefuls. The action continues on Monday Night Football, where Jaxon Dart and the New York Giants visit Matthew Stafford and the Los Angeles Rams to close out Week 2 under the lights.