Find NFL odds for Week 6 of the 2026 season on DraftKings Sportsbook!

Week 6 begins Thursday, October 15, when the Seattle Seahawks visit the Denver Broncos. Bo Nix and the Broncos face a Seahawks offense featuring wide receiver Jaxon Smith-Njigba in a primetime matchup that could have early playoff implications for two competitive conference teams.

Sunday’s most anticipated matchup sends Justin Herbert and the Los Angeles Chargers to Kansas City to face Patrick Mahomes and the Kansas City Chiefs. The AFC West showdown gives bettors a marquee quarterback matchup, while the Buffalo Bills visit the Las Vegas Raiders later in the afternoon. Josh Allen and the Bills will look to make a statement on the road against a divisional opponent.

Sunday Night Football features Dak Prescott and the Dallas Cowboys at the Green Bay Packers. Green Bay and Jordan Love host one of the league’s most recognizable rivalries in a game filled with potential player-prop and anytime touchdown betting opportunities.

Week 6 concludes Monday, October 19, with Jayden Daniels and the Washington Commanders visiting Brock Purdy and the San Francisco 49ers. The primetime matchup offers a compelling NFC test as both teams look to build momentum heading into the middle of the season.