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The 2026 season kicks off with a special Wednesday night opener as the defending Super Bowl champion Seattle Seahawks welcome Drake Maye and the New England Patriots to Lumen Field. Despite the departure of Super Bowl LX MVP Kenneth Walker, the Seahawks enter the season opener as favorites according to the latest NFL Week 1 odds. 

Week 1 also features the NFL's first-ever regular season game in Australia, where NFC West rivals the San Francisco 49ers and the Los Angeles Rams meet at the Melbourne Cricket Ground. With stars like Brock Purdy, Christian McCaffrey, Matthew Stafford, Puka Nacua, and Davante Adams taking the field, fans will be treated to one of Week 1's most anticipated games.

Sunday Night Football renews one of the league's biggest rivalries as Dak Prescott and the Dallas Cowboys travel to MetLife Stadium to take on Jaxson Dart and the New York Giants. Both teams enter the season looking to rebound, making this NFC East showdown an intriguing way to cap off Sunday's slate.

Week 1 concludes on Monday Night Football with an AFC West battle between the Denver Broncos and Kansas City Chiefs. The Broncos look to build on last season's division title, while the Chiefs aim to reclaim the AFC West crown behind Patrick Mahomes at Arrowhead Stadium.