Explore NFL Week 1 odds on DraftKings Sportsbook, with opening-week matchups across the league, including a Super Bowl LX rematch and the NFL’s first regular-season game in Australia.

Wednesday night’s season opener features the defending champion Seattle Seahawks hosting Drake Maye and the New England Patriots at Lumen Field. Seattle and New England meet again after facing off in Super Bowl LX.

Week 1 also brings the NFL’s first regular-season game in Australia, as the San Francisco 49ers and Los Angeles Rams meet at the Melbourne Cricket Ground. The NFC West rivals face off in one of the most anticipated matchups of opening week.

Sunday Night Football opens with an NFC East rivalry as Dak Prescott and the Dallas Cowboys visit the New York Giants at MetLife Stadium. Both teams enter 2026 looking to rebound from difficult 2025 campaigns, adding extra stakes to this divisional matchup.

Week 1 concludes on Monday Night Football with the Denver Broncos visiting the Kansas City Chiefs. Denver ended Kansas City’s nine-year run as AFC West champion last season, and the Chiefs will look to begin their push to reclaim the division behind Patrick Mahomes at Arrowhead Stadium.