Find NFL odds for Week 5 for the 2026 season on DraftKings Sportsbook!

Week 5 begins Thursday, October 8, when Dak Prescott, CeeDee Lamb, and the Dallas Cowboys host the Tampa Bay Buccaneers. Tampa Bay will be without safety Antoine Winfield Jr. as he recovers from a rib injury, while quarterback Baker Mayfield’s thumb injury remains a major storyline heading into the game.

Sunday’s slate features several highly anticipated matchups, including the Philadelphia Eagles and Jacksonville Jaguars meeting in London. The weekend’s biggest divisional showdown comes when the undefeated San Francisco 49ers visit the Seattle Seahawks. San Francisco will look to keep its early-season momentum going despite defensive concerns surrounding Nick Bosa, while Seattle could be without running back Zach Charbonnet. The late-afternoon window also includes the Detroit Lions at Arizona Cardinals, before the Baltimore Ravens visit the Atlanta Falcons on Sunday Night Football. 

Week 5 concludes Monday, October 12, with Josh Allen, James Cook, and the Buffalo Bills facing Matthew Stafford and the Los Angeles Rams, an interconference matchup with early playoff implications.